Interventional Cardiology Research

Interventional Cardiology Research involves the combination of standard clinical practices along with the latest medical therapies. Research in this area includes new interventional devices (drug eluting stents, distal protection devices, Patent Foramen Ovale (PFO) closure devices, etc.) and advanced drug therapies for patients who are undergoing balloon angioplasty and/or stent placement in the arteries of their heart. Advancement in the care of patients is based on research studies conducted and their outcomes. Patients play an important role in the success of our research studies. Patient participation is greatly appreciated, for without their help new advancements in medical therapies would not be possible.

Current Research Studies:

• COSTAR II: CObalt chromium STent with Antiproliferative for Restenosis II Trial
• Triton: A Comparison of [Prasugrel] CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects who are to Undergo Percutaneous Coronary Intervention TIMI-38
• Spirit III: A Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the treatment of subjects with de novo Native Coronary Artery lesions
• Sepia-PCI: New anticoagulation drug in PCI
• Periscope Trial
• JOSTENT Registry: Registry for Jomed stent for perforations
• CORAL: Cardiovascular Outcomes in Renal Atherosclerotic Lesions
• RESPECT: Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment
• ZoMaxx II Trial
• Effect of Clopidogrel vs. Placebo, on a Background of Standard Care including Aspirin, in Maintining the Patency of Lower Limb Arteries After Angioplasty
• CARDIA STAR™ Trial: A United States Randomized Clinical Trial of the CARDIA STAR™ Patent Foramen Ovale Closure System (The CARDIA STAR™ Trial)

Research Studies that are closed to new patients/follow-up only:

• PBAV Study: Influence of External Beam Aortic Valve Radiation on Restenosis Following Successful Percutaneous Balloon Valvuloplasty in Elderly or Poor Surgical Risk Patients with Severe Aortic Stenosis
• ENDEAVOR III: A Randomized Controlled Trial of the Medtronic Endeavor Drug (ABT-578) Eluting Stent System versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions
• SIRIUS – 4.0mm: A Multi-center, non-randomized study of the 4.0 mm CYPHER™ Sirolimus-Eluting Coronary Stent in the Treatment of Patients with DeNovo Native Coronary Artery Lesions
• TAXUS V-ISR: A Prospective, Randomized Trial Evaluating the Slow-Release Formulation TAXUS™ Paclitaxel-Eluting Coronary Stent in the Treatment of In-stent Restenosis
• D-Stat: D-stat Patch vs. Placebo patch post-angio
• IVS Clip Closure In Percutaneous Procedure - “The CLIP Study”
• ACTIVATE Trial: A New Drug Study To Reduce The Progression Of Atherosclerosis
• BARRICADE Trial: The Barrier Approach to Restenosis: Restrict Intima and Curtail Adverse Events
• PREVAIL Trial
• PROXIMAL Trial: Proximal Protection During Saphenous Vein Graft Interventions Using the Proxis™ Embolic Protection System.
• Angiomax™ in Renal Insufficiency Trial
• SIRIUS Direct
• SISR: A Multicenter Randomized Study of the Sirolimus-eluting Bx VELOCITY Balloon Expandable Stent vs. Intravascular Brachytherapy in the Treatment of Patients with In-Stent Restenotic coronary artery lesions
• SYMBIOT III: A Prospective Randomized Trial Evaluating the Symbiot III Covered Stent System In Saphenous Vein Grafts
• TAXUS V:A Randomized Double-blind Trial to Access TAXUS Paclitaxel-eluting Coronary Stents, Slow Release Formulation, in the Treatment of High Risk de novo Coronary Lesions

Click here to view a list of archived Interventional Cardiology Research

• M. Nicholas Burke, MD
• Ivan J. Chavez, MD, FACC
• Kevin M. Harris, MD, FACC, FASE
• Timothy D. Henry, MD, FACC
• Vib R. Kshettry, MD
• John R. Lesser, MD, FACC
• Daniel Lips, MD, FACC
• Terrence F. Longe, MD, FACC
• James D. Madison, MD, FACC
• Michael R. Mooney, MD, FACC
• Wesley R. Pedersen, MD, FACC
• Anil K. Poulose, MD, FACC
• Robert S. Schwartz, MD, FACC
• Jay H. Traverse, MD, FACC, FAHA
• Robert A. Van Tassel, MD, FACC
• Yale Wang, MD, FACC, FSCAI
• Barry G. Welge, MD

• Peg Demmer, RN
• Holly MacDonald, RN
• Gretchen Peichel, RN
• Talia Pierce, RN
• Denise Windenburg, CCRC

For more information about the interventional cardiology research program at the Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, please contact Carol Stone at 612-863-9124.